Antibodies to human T-lymphotropic virus type-I in sufferers with tropical spastic paraparesis.
10 out of 17 (59%) sufferers with tropical spastic paraparesis (TSP) had antibodies to human T-lymphotropic virus-I (HTLV-I), as did 5 out of 5 TSP sufferers with systemic signs. Solely 13 out of 303 (4%) controls, made up of blood donors, medical personnel, and different neurological sufferers, had such antibodies.
These findings recommend both that HTLV-I is neurotropic or that the virus or a associated one contributes to the pathogenesis of TSP.
SLC52A1 Antibody, HRP conjugated
Estrogens are outlined by their skill to induce the proliferation of cells of the feminine genital tract. The huge chemical range of estrogenic compounds precludes an correct prediction of estrogenic exercise on the premise of chemical construction.
Rodent bioassays will not be suited to the large-scale screening of chemical substances earlier than their launch into the atmosphere due to their price, complexity, and moral issues.
The E-SCREEN assay was developed to evaluate the estrogenicity of environmental chemical substances utilizing the proliferative impact of estrogens on their goal cells as an finish level.
This quantitative assay compares the cell quantity achieved by related inocula of MCF-7 cells within the absence of estrogens (damaging management) and within the presence of 17 beta-estradiol (constructive management) and a spread of concentrations of chemical substances suspected to be estrogenic.
Among the many compounds examined, a number of “new” estrogens have been discovered; alkylphenols, phthalates, some PCB congeners and hydroxylated PCBs, and the pesticides dieldrin, endosulfan, and toxaphene have been estrogenic by the E-SCREEN assay.
As well as, these compounds competed with estradiol for binding to the estrogen receptor and elevated the degrees of progesterone receptor and pS2 in MCF-7 cells, as anticipated from estrogen mimics. Recombinant human development components (bFGF, EGF, IGF-1) and insulin didn’t improve in cell yields.
The goals of the work summarized on this paper have been a) to validate the E-SCREEN assay; b) to display a wide range of chemical substances current within the atmosphere to determine these that could be inflicting reproductive results in wildlife and people; c) to evaluate whether or not environmental estrogens could act cumulatively; and at last d) to debate the reliability of this and different assays to display chemical substances for his or her estrogenicity earlier than they’re launched into the atmosphere.
Description: A polyclonal antibody against SLC52A1. Recognizes SLC52A1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against SLC52A1. Recognizes SLC52A1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
Description: A polyclonal antibody against SLC52A1. Recognizes SLC52A1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids.
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.
ELISA kit for Human Anti-AsAb (Anti-Anti-Sperm Antibody Antibody)
Description: A competitive Inhibition ELISA kit for detection of Anti-Anti-Sperm Antibody Antibody from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Numerical sediment high quality pointers (SQGs) for freshwater ecosystems have beforehand been developed utilizing a wide range of approaches.
Every strategy has sure benefits and limitations which affect their software within the sediment high quality evaluation course of. In an effort to concentrate on the settlement amongst these varied revealed SQGs, consensus-based SQGs have been developed for 28 chemical substances of concern in freshwater sediments (i.e., metals, polycyclic fragrant hydrocarbons, polychlorinatedbiphenyls, and pesticides).
For every contaminant of concern, two SQGs have been developed from the revealed SQGs, together with a threshold impact focus (TEC) and a possible impact focus (PEC).
The resultant SQGs for every chemical have been evaluated for reliability utilizing matching sediment chemistry and toxicity information from discipline research performed all through the USA.
The outcomes of this analysis indicated that a lot of the TECs (i.e., 21 of 28) present an correct foundation for predicting the absence of sediment toxicity. Equally, a lot of the PECs (i.e., 16 of 28) present an correct foundation for predicting sediment toxicity.
Imply PEC quotients have been calculated to guage the mixed results of a number of contaminants in sediment. Outcomes of the analysis point out that the incidence of toxicity is very correlated to the imply PEC quotient (R(2) = 0.98 for 347 samples).
It was concluded that the consensus-based SQGs present a dependable foundation for assessing sediment high quality circumstances in freshwater ecosystems.
Anti-Anti-SEPT4 Antibody antibody
Halogenated fragrant compounds, typified by the polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs), and diphenylethers (PCDEs), are industrial compounds or byproducts which have been broadly recognized within the atmosphere and in chemical-waste dumpsites.
Halogenated aromatics are invariably current in numerous analytes as extremely complicated mixtures of isomers and congeners and this complicates the hazard and threat evaluation of those compounds.
A number of research have confirmed the frequent receptor-mediated mechanism of motion of poisonous halogenated aromatics and this has resulted within the growth of structure-activity relationships for this class of chemical substances.
Probably the most poisonous halogenated fragrant is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and primarily based on in vivo and in vitro research the relative toxicities of particular person halogenated aromatics have been decided relative to TCDD (i.e., poisonous equivalents).
The derived poisonous equivalents can be utilized for hazard and threat evaluation of halogenated fragrant mixtures; furthermore, for extra complicated mixtures containing congeners for which no requirements can be found (e.g., bromo/chloro mixtures), a number of in vitro or in vivo assays will be utilized for hazard or threat evaluation.
Anti-Anti-SEPT5 Antibody antibody
Description: This gene is a member of the septin gene household of nucleotide binding proteins, initially described in yeast as cell division cycle regulatory proteins.
Septins are extremely conserved in yeast, Drosophila, and mouse and seem to manage cytoskeletal group. Disruption of septin operate disturbs cytokinesis and leads to massive multinucleate or polyploid cells.
This gene is mapped to 22q11, the area regularly deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has additionally been reported in sufferers with acute myeloid leukemia. Different splicing leads to a number of transcript variants.
platelet
in read-through transcription into the downstream neighboring gene (GP1BB; glycoprotein Ib), whereby bigger, non-coding transcripts are produced.
Description: A polyclonal antibody against RXFP3. Recognizes RXFP3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100
Description: A polyclonal antibody against RXFP3. Recognizes RXFP3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000
Description: A polyclonal antibody against RXFP3. Recognizes RXFP3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100
Description: A polyclonal antibody against RXFP3. Recognizes RXFP3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200
Description: A polyclonal antibody against RXFP3. Recognizes RXFP3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Description: Description of target: RXFP3 is the receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.064ng/mL
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RXFP3 (C-term). This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RXFP3 (C-Terminus). This antibody is tested and proven to work in the following applications:
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RXFP3 (Cytoplasmic Domain). This antibody is tested and proven to work in the following applications:
Description: Quantitative sandwich ELISA for measuring Human Relaxin-3 receptor 1 (RXFP3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Human Relaxin-3 receptor 1 (RXFP3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Human Relaxin-3 receptor 1 (RXFP3) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) Antibody
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) in Tissue homogenates, cell lysates and other biological fluids.
Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) in Tissue homogenates, cell lysates and other biological fluids.
Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) in Tissue homogenates, cell lysates and other biological fluids.
Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) ELISA Kit
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) in Tissue homogenates, cell lysates and other biological fluids.
Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) ELISA Kit
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Relaxin/Insulin Like Family Peptide Receptor 3 (RXFP3) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.
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